PDSNGL® S

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PDSNGL® S is a premium-grade, Single-source Polydeoxyribonucleotide (PDRN) ingredient obtained exclusively from highly purified Salmo Salar DNA, purified to contain DNA fragments 50–1500 kDa. Widely used in injection therapy for hair growth and supportive for skin and wound regeneration.

Cat No: EG-RM-PDS-1-5 L

PRODUCT INFORMATION                        

 

 I. TECHNICAL SPECIFICATIONS

Structural / Composition Data

Structure / Formula

 Polydeoxyribonucleotide; linear polymer of 2'-deoxyribonucleotides (50-1500 base pairs)

Molecular Weight

 ~50 - 1,500 kDa (Mixture of fragments)
 PDRN can be categorized into three molecular weight fractions:

Ultra Low

(50–100 kDa)

Low

(100–500 kDa)

Medium

(500–1500 kDa)

Appearance

 Liquid

Concentration

 15% 

Solubility

 Soluble in aqueous buffers (e.g., saline, sterile water)

Form(s) Available

 Sterile solution

Stability & Shelf Life

Storage

 12 months at 2–8 °C, >24 months at –20 °C

Post-Reconstitution

  6-12 months at 2–8 °C

Stability Notes

 Protect from light

Quality & Compliance

QC Tests

 Confirmed

Media

 Buffer PBS

Documentation

 Available on request

 

 II. PREPARATION / RECONSTITUTION

General Guidance

 Reconstitute with 100 mL sterile PBS.

Recommendations

 Use within 8–12 hours refrigerated.

 

 III. MECHANISM & BIOLOGICAL FUNCTION

Mechanism of Action

 Binds to and activates the Adenosine A2A Receptor (A2AR). Acts as a "building block" and signaling molecule, promoting tissue repair and modulating inflammation. Promotes angiogenesis via VEGF upregulation. 

Biological Claims

 • Stimulation of hair growth 

 • Powerful Anti-Inflammatory Action

 •Collagen Synthesis & Fibroblast Proliferation

 • Stimulation of Angiogenesis (new blood vessel formation)

 • Tissue Regeneration & Wound Healing

 

 IV. APPLICATIONS

Intended Uses

 Targeted drug delivery systems

 

 V. PACKAGING & PRESENTATION

  

Sizes

  

1-5 Liters

        

PDSNGL® S

PDSNGL® S
PDSNGL® S

FEATURES AND KIENTICS

PDSNGL® -S is ideal for incorporation into wound healing products, scar management therapies, anti-aging formulations, and hair-follicle revitalization treatments, where high-purity polynucleotides are desired to stimulate angiogenesis, fibroblast activity, collagen production, and antioxidant defenses.

Sterile
Suitable for injectable &microneedles
Stable
Bioactive
High-purity standard for safety
Stimulates skin cell repair

Mechanism of Action

1
PDRN binds to adenosine A2A receptors
2
Initiating a cascade that raises intracellular cAMP levels.
3
PDRN provides ready-made deoxyribonucleotides that act as building blocks for DNA repair
Mechanism illustrative image

What's inside ?

inside_image1

Purified DNA fragments

inside_image2

Effective cellular stimulation

inside_image3

clinically used

inside_image4

Supports hair growth

inside_image5

Promotes skin healing

inside_image6

High-purity extraction

Optimal Delivery System

Morning Ritual

Cream

Morning Ritual

Injectable

Morning Ritual

Hydrogel matrices

Common Questions

How does PDSNGL ™-S act at the cellular level to promote tissue repair or hair growth?

PDSNGL® -S delivers highly purified, low-molecular-weight polydeoxyribonucleotides that are rapidly metabolized into nucleotides and nucleosides by local enzymes. These building blocks support DNA , accelerate cell metabolism, and activate purinergic (A₂A) receptors, which in turn stimulate fibroblast proliferation, collagen and extracellular-matrix production, angiogenesis, and anti-inflammatory signaling. Together these effects create an optimal microenvironment for faster wound closure, improved skin regeneration, and revitalization of hair follicles through enhanced vascular supply and prolonged anagen (growth) phase activity.

What clinical or preclinical data support the use of PDSNGL™-S in regenerative therapies?

The underlying active—single-source salmon-derived PDRN—has been investigated in multiple peer-reviewed preclinical and clinical studies demonstrating accelerated wound healing, enhanced angiogenesis, and increased hair density when applied topically or via injection.
PDSNGL® -S uses the same active principle but with tighter fragment-size control and enhanced purification to deliver consistent, reproducible performance. 

Is Salmon PDRN suitable for cosmetic formulations?

Yes. It is highly suitable for:
Serums
Ampoules
Creams
Scalp treatments
Mesotherapy formulations

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