PDSNGL®- B from probiotics and it’s a Bioactive DNA derived from Lacticaseibacillus casei safe probiotic strains , designed to deliver the regenerative power of highly purified polynucleotides in a stable, ready-to-use form.
Its balanced composition makes it ideal for advanced skin rejuvenation, wound repair, and hair-growth–support applications, either on its own or in combination with hyaluronic acid, growth factors, or device-based delivery systems.
Cat No: EG-RM-PDB-1-5 L
PRODUCT INFORMATION
I. TECHNICAL SPECIFICATIONS
Structural / Composition Data
Structure / Formula
Polydeoxyribonucleotide; linear polymer of 2'-deoxyribonucleotides
Molecular Weight
~50 - 1,500 kDa (Mixture of fragments)
PDRN can be categorized into three molecular weight fractions:
Ultra Low
(50–100 kDa)
Low
(100–500 kDa)
Medium
(500–1500 kDa)
Appearance
Liquid
Concentration
15%
Solubility
Soluble in aqueous buffers (e.g., saline, sterile water)
Form(s) Available
Sterile solution
Stability & Shelf Life
Storage
12 months at 2–8 °C, >24 months at –20 °C
Post-Reconstitution
6-12 months at 2–8 °C
Stability Notes
Protect from light
Quality & Compliance
QC Tests
Confirmed
Media
Buffer PBS
Documentation
Available on request
II. PREPARATION / RECONSTITUTION
General Guidance
Reconstitute with 100 mL sterile PBS.
Recommendations
Use within 8–12 hours refrigerated.
III. MECHANISM & BIOLOGICAL FUNCTION
Mechanism of Action
Binds to and activates the Adenosine A2A Receptor (A2AR). Acts as a "building block" and signaling molecule, promoting tissue repair and modulating inflammation. Promotes angiogenesis via VEGF upregulation.
Biological Claims
• Tissue Regeneration & Wound Healing
• Powerful Anti-Inflammatory Action
• Stimulation of Angiogenesis (new blood vessel formation)
• Collagen Synthesis & Fibroblast Proliferation
IV. APPLICATIONS
Intended Uses
Targeted drug delivery systems
V. PACKAGING & PRESENTATION
Sizes
1-5 Liter
PDSNGL® B
FEATURES AND KIENTICS
PDSNGL® -B is a highly purified polynucleotide that safely stimulates collagen synthesis, microcirculation and cell renewal, offering versatile delivery and easy integration into advanced skin and scalp regeneration therapies.
Heat and pH stable
High purity, non-immunogenic, and microbiome-safe
Sustainable, bio fermentation-based technology
Compatible with topical, injectable
probiotic DNA with molecular size (100–800 bp)
Derived from safe probiotic strains
Mechanism of Action
1
PDRN binds to adenosine A2A receptors
2
Initiating a cascade that raises intracellular cAMP levels.
3
PDRN provides ready-made deoxyribonucleotides that act as building blocks for DNA repair
What's inside ?
Bioactive DNA complex derived from safe probiotic strains.
Next-generation PDRN with regenerative and anti-inflammatory properties
Supports hair growth by revitalizing follicles and scalp health
Promotes skin healing & healthier skin
Enhances wound care
High purity grade
Optimal Delivery System
Creams
Injectables
Hydrogel matrices
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What is PDSNGL® B and what makes it unique compared to other polynucleotide or PDRN ingredients?
PDSNGL® B is a highly purified, polynucleotide sourced from a controlled biological origin. Unlike standard PDRN or generic polynucleotide blends, PDSNGL™-B is produced with tight molecular-weight yielding a reproducible, low-immunogenicity ingredient that is optimized for regenerative dermatology and trichology applications.
How does PDSNGL®- B support tissue regeneration, wound healing or hair growth at the cellular level?
PDSNGL®-B provides bioavailable DNA fragments and nucleotides that act as precursors for cell metabolism and activate adenosine A₂ receptors, leading to increased fibroblast proliferation, collagen synthesis, angiogenesis and improved microcirculation. These combined effects accelerate tissue repair, improve extracellular-matrix quality, and stimulate hair-follicle activity for healthier scalp and hair growth.
Are there any known risk factor, sensitivities or regulatory considerations for using PDSNGL®-B?
PDSNGL®- B is designed to be biocompatible and non-immunogenic, and each batch is tested for endotoxins, residual proteins and microbial contamination.
